Charissa, Luk: First, I want to congratulate you on your dedication to accomplish this really interesting work! I have done a review of this interesting work I have a couple of questions that you may help me to answer: Do you know or have an idea about the factors that determine the affinity of the rilpivirine analogs when they bind to the NNRTIs protein? Is the affinity of the rilpivirine analogs for the NNRTIs protein modified by the trifluoromethoxy groups and the pi-pi interaction of the benzene rings?